The term atherothrombosis encompasses two overlapping areas of research, atherosclerosis and thrombosis. Atherosclerosis affects large arteries of the body, and when complicated by plaque rupture and/or thrombosis may lead to acute myocardial infarction or stroke. Thrombosis, which arises from a maladaptive shift in the hemostatic balance towards the procoagulant side may affect not only large arteries, but also veins and small vessels.
The CVBR has expertise in several areas related to atherosclerosis and thrombosis. Most notably, structural biologists have been involved in solving the structure of clotting proteins, cell/molecular biologists are focused on the molecular basis of lipoprotein metabolism and the role of the endothelium in mediating hemostatic balance, and translational investigators are studying the hemostatic system in mouse models of sepsis.