Angiogenesis Research

Angiogenesis, the sprouting and proliferation of endothelial cells from pre-existing blood vessels is a biological process on which all growing tissues rely. As an important corollary, angiogenesis may play a pathophysiological role in many diseases, including tumors, diabetic retinopathy and wound healing. Notably anti-angiogenesis therapy has recently emerged as an important adjunct to therapy of certain cancers.


A key focus of the CVBR is to delineate molecular pathways underlying physiological and pathological angiogenesis, and to identify novel diagnostic and therapeutic targets. Areas of interest include placental growth, tumor angiogenesis, wound repair, retinopathy of prematurity, and neovascularization of ischemic tissue.
Bentley

Research area:
Computational Modeling of the Vasculature
Katie Bentley, Ph.D.

 
H. Dvorak

Research area:
Vascular Permeability, Arteriogenesis, Venogenesis, Lymphangiogenesis
Harold Dvorak, M.D.

 
Grant

Research area:
Protein Structure-Function and Biomolecular Recognition
Marianne Grant, Ph.D.

 
Jaminet

Research area:
Intercellular Communication and Angiogenesis
Shou-Ching S. Jaminet, Ph.D.

 
Kaczmarek

Research area:
P2 receptor signaling in endothelial cells
Elzbieta Kaczmarek, Ph.D.

 
Karumanchi

Research area:
Angiogenic Factors in Health & Disease
S. Ananth Karumanchi, Ph.D.

 
Lawler

Research area:
Tissue Remodeling & Angiogenesis by Thrombospondins
Jack Lawler, Ph.D.

 
Nagy

Research area:
VEGF and the Pathological Vascular Phenotype
Janice A. Nagy, Ph.D.

 
Nucera

Research area:
Endocrine/thyroid cancer translational research (role of BRAFV600E in the angiogenic microenvironment and metabolism)
Carmelo Nucera, M.D., Ph.D.

 
Senger

Research area:
Capillary Morphogenesis
Donald Senger, Ph.D.

 
Yuan

Research area:
Vascular Niche/Cardiomyocyte Function & Metabolism
Lei Yuan, M.D., Ph.D.

 
Zeng

Research area:
Signaling pathways of angiogenesis
Huiyan Zeng, Ph.D.

 
Zhao

Research area:
Signaling in Pathogenic Angiogenesis
Dezheng Zhao, Ph.D.