Angiogenesis Research

Angiogenesis, the sprouting and proliferation of endothelial cells from pre-existing blood vessels is a biological process on which all growing tissues rely. As an important corollary, angiogenesis may play a pathophysiological role in many diseases, including tumors, diabetic retinopathy and wound healing. Notably anti-angiogenesis therapy has recently emerged as an important adjunct to therapy of certain cancers.

A key focus of the CVBR is to delineate molecular pathways underlying physiological and pathological angiogenesis, and to identify novel diagnostic and therapeutic targets. Areas of interest include placental growth, tumor angiogenesis, wound repair, retinopathy of prematurity, and neovascularization of ischemic tissue.

Research area:
Computational Modeling of the Vasculature
Katie Bentley, Ph.D.

H. Dvorak

Research area:
Vascular Permeability, Arteriogenesis, Venogenesis, Lymphangiogenesis
Harold Dvorak, M.D.


Research area:
Protein Structure-Function and Biomolecular Recognition
Marianne Grant, Ph.D.


Research area:
Intercellular Communication and Angiogenesis
Shou-Ching S. Jaminet, Ph.D.


Research area:
P2 receptor signaling in endothelial cells
Elzbieta Kaczmarek, Ph.D.


Research area:
Angiogenic Factors in Health & Disease
S. Ananth Karumanchi, Ph.D.


Research area:
Tissue Remodeling & Angiogenesis by Thrombospondins
Jack Lawler, Ph.D.


Research area:
VEGF and the Pathological Vascular Phenotype
Janice A. Nagy, Ph.D.


Research area:
Endocrine/thyroid cancer translational research (role of BRAFV600E in the angiogenic microenvironment and metabolism)
Carmelo Nucera, M.D., Ph.D.


Research area:
Capillary Morphogenesis
Donald Senger, Ph.D.


Research area:
Vascular Niche/Cardiomyocyte Function & Metabolism
Lei Yuan, M.D., Ph.D.


Research area:
Signaling pathways of angiogenesis
Huiyan Zeng, Ph.D.


Research area:
Signaling in Pathogenic Angiogenesis
Dezheng Zhao, Ph.D.