Dezheng . Zhao, Ph.D.
Assistant Professor of Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School
330 Brookline Avenue, RN-270J
Boston, MA 02215
Office Phone: 617-667-0466
Ph.D. in Biochemistry in 2000 from Boston University. Postdoctoral fellow at BIDMC from 2000-2002. Instructor of Medicine from 2002-2007. Appointed Assistant Professor of Medicine in 2007.
Research Interests: Signaling in Pathogenic Angiogenesis
Basic Research - This laboratory has two main research interests: (1) function and molecular mechanism of orphan nuclear receptor Nur77 family members in pathological angiogenesis and related diseases particularly inflammatory bowel diseases and colon cancer; and (2) function and mechanism of neuropeptides in pathological angiogeneis, inflammatory bowel diseases and colon cancer.
New and Noteworthy Publications:
Zhao D*, Zhan Y, Zeng H, Koon HK, Moyer MP, Pothoulakis C. Neurotensin stimulates expression of early growth response-gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. Int J Cancer, 2007, 120:1652-1656. (*Corresponding Author)
Zhao D*, Desai S, Zeng H. VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression: role in VEGF-induced angiogenesis. Int J Cancer 2011, 128:2602-12. (*Corresponding and senior author).
Liu X*, Zhao D*, James L, Li J, Zeng H. Requirement of the nuclear localization of transcription enhancer factor 3 (TEF3) for proliferation, migration, tube formation and angiogenesis induced by vascular endothelial growth factor. FASEB J. 2011, 25:1188-97. ( *Equal 1st authors)
Zhao D*, Bakirtzi K, Zhan Y, Zeng H, Koon HW, Pothoulakis C. Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative response of neurotensin in human colonic epithelial cells. J Biol Chem. 2011, 286: 6092-9. (*Corresponding author)
Zhao D, Qin L, Bourbon PM, James L, Dvorak HF, Zeng H. TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions. Proc Natl Acad Sci USA 2011, 108(29):12066-71. (Direct submission)