Leena . Pradhan-Nabzdyk, Ph.D., M.B.A
Assistant Professor of Surgery
Frank W. LoGerfo Division of Vascular and Endovascular Surgery
Beth Israel Deaconess Medical Center
Harvard Medical School
330 Brookline Avenue, Stm-8M-10E
Boston, MA 02215
Office Phone: 617-667-0096
Leena received her Ph.D. in Pharmacology from Tulane University, New Orleans, LA. After completing a year of postdoctoral fellowship at Tulane University School of Medicine, Leena joined the Division of Vascular and Endovascular Surgery at BIDMC, Harvard Medical School as an Instructor in Surgery and is currently, an Assistant Professor of Surgery. While working as an Assistant Professor, Leena also received her MBA from the Executive MBA program of the Massachusetts Institute of Technology, Sloan School of Management.
Research Interests: Diabetic Wound Healing and Vascular Graft Failure
Basic Research -
Diabetic Wound Healing: We are currently working on understanding the mechanisms underlying diabetic wound healing. The research is focused on delineating the role of neuropeptides and vascular ischemia in wound healing and chronic skin inflammation. To that end, the lab has developed a rabbit model of diabetic neuroischemic wound healing and used this model to not only investigate wound healing pathways but also test novel therapeutics.
Vascular Graft Failure: This project focuses on investigating causes of vein graft and prosthetic graft failure. Additionally, the goal is to develop therapies/devices using bioengineering approaches to deliver therapeutics to prevent or limit initimal hyperplasia, the leading cause of graft failure.
TRAINING PROGRAMS: NIH T32 AND NIH T35
Leena is a mentor and member of the Training Program Executive Committee of the Harvard Longwood Research Training in Vascular Surgery (NIH T32) program currently in its 23rd year. This training program recruits surgery residents who plan to conduct at least two years of research in the field of vascular surgery. In addition to the T32 program, Leena is also a mentor and Co-Director of the Harvard Longwood Short-Term Research Training in Vascular Surgery (NIH T35) program. This program recruits first year medical students from all over the country to conduct 8-12 weeks of research in vascular surgery. For both the training programs, Leena is responsible for the overall operations including mentor selection, trainee recruitment, curriculum development and grant renewal.
New and Noteworthy Publications:
Bodewes TC, Johnson JM, Auster M, Huynh C, Muralidharan S, Contreras M, LoGerfo FW, Pradhan-Nabzdyk L.. Intraluminal delivery of thrombospondin-2 small interfering RNA inhibits the vascular response to injury in a rat carotid balloon angioplasty model. FASEB J. 2016 Sep 26. [Epub ahead of print]. PMC in process.
Tellechea A, Leal EC, Kafanas A, Auster ME, Kuchibhotla S, Ostrovsky Y, Tecilazich F, Baltzis D, Zheng J, Carvalho E, Zabolotny JM, Weng Z, Petra A, Patel A, Panagiotidou S, Pradhan Nabzdyk L, Theoharides TC, Veves A.. Role of Mast Cells in Impaired Diabetic Wound Healing. Diabetes, 2016 Jul; 65(7):2006-2019. PMCID: PMC4915574.
Raof NA, Rajamani D, Chu HC, Gurav A, Johnson JM, LoGerfo FW, Bhasin M, Pradhan-Nabzdyk L.. The effects of transfection reagent polyethyleneimine (PEI) and non-targeting control siRNAs on global gene expression in human aortic smooth muscle cells. BMC Genomics. 2016 Jan 5;17(1):20. http://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-2267-9 PMCID: PMC4700750. .
Nabzdyk CS, Chun MC, Oliver-Allen HS, Pathan SG, Phaneuf MD, You JO, Pradhan-Nabzdyk LK*, LoGerfo FW.. Gene silencing in human aortic smooth muscle cells induced by PEI-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts. Biomaterials. 2014 Mar;35(9):3071-9. doi: 10.1016/j.biomaterials.2013.12.026. Epub 2014 Jan 4. PMID: 24397987 [PubMed - in process] (*=Co-Senior Author)..
Pradhan-Nabzdyk L, Kuchibhotla S, Guthrie P, Chun M, Auster M, Nabzdyk C, Deso S, Andersen N, LoGerfo FW, Veves A.. Expression of neuropeptides and cytokines in a novel rabbit model of diabetic neuroischemic wound healing. J Vasc Surg. 2013 Sep;58(3):766-775. PMCID: PMC3755034.