Carmelo . Nucera, MD, PhD
Assistant Professor at Harvard Medical School
Beth Israel Deaconess Medical Center
Harvard Medical School
330 Brookline Avenue, RN-270G
Boston, MA 02215
Office Phone: 617-667-5964
Office Fax: 617-667-3591
Carmelo Nucera, M.D., Ph.D., is currently an Assistant Professor at Harvard Medical School, Boston, in the Division of Cancer Biology and Angiogenesis (Department of Pathology), Beth Israel Deaconess Medical Center. Dr. Nucera received his M.D. and Ph.D. in Experimental Endocrinology and Metabolism from Italy. Dr. Nucera is highly driven by an intense desire to make important contributions that will directly benefit patients. Dr. Nucera is strongly committed to make discovery aimed to immediately cure patients that are suffering with aggressive tumors and rare/orphan cancer disease. Dr. Nucera has a clinical background and intensely served patients with fatal human diseases. He did his residency in Endocrinology and Metabolic Diseases in Italy, and he was also trained as research fellow at the Regina Elena Cancer Institute and ‘A. Gemelli’ Medical School in Roma (Italy). He was trained during his Ph.D. and post-doctoral fellowship at Harvard Medical School (Massachusetts General Hospital and Beth Israel Deaconess Medical Center) and he was recruited as Instructor in the Department of Pathology at the Beth Israel Deaconess Medical Center/Harvard Medical School in the 2009. He was promoted Assistant Professor at Harvard Medical School in the 2013. Dr. Nucera has been the recipient of many National and International awards and is serving the research community on different advisory committees of different Foundations and Associations, including the American Thyroid Association (ATA) Research Committee. He is a Principal Investigator on thyroid cancer translational research studies as well as an invited presenter at medical conferences, both nationally and internationally. Dr. Nucera has assisted many international journals as invited reviewer, or as associate editor. He is actively involved in tutoring and teaching medical students, research fellows, and basic scientists at Harvard Medical School. He was the recipient of an ATA Thyroid Cancer Award. He aims to pursue his interest in thyroid cancer research engaging in both basic science and translational/clinical research, and teaching. His laboratory includes translational projects focused on understanding metastatic/advanced thyroid cancers and developing targeted therapies, assess tumor biomarkers as well as unravel pathogenesis of ‘orphan and rare tumor diseases’. In particular, his research program uses a powerful, multidisciplinary approach to provide new insights into the role of BRAFV600E in the milieu of human metastatic thyroid cancers, and of ‘orphan and rare tumor diseases’.
Research Interests: Endocrine/thyroid cancer translational research (role of BRAFV600E in the angiogenic microenvironment and metabolism
Basic Research - I am an MD/PhD with specialty in endocrine cancers and I’m developing as Assistant Professor at Harvard Medical School a research program in the "Division of Cancer Biology and Angiogenesis" at the Beth Israel Deaconess Medical Center/Harvard Medical School, focused on "preclinical and translational models of human thyroid cancer with an emphasis on mechanisms of metastatic networks, new models of in vitro angiogenesis, tumor microenvironment, and metabolic regulations, using and dissecting new targeted therapies anti-BRAFV600E. I am primarily engaged in basic and translational thyroid cancer research, but also actively participate in tutoring and teaching activities to basic science students and medical students. I have 10-years of research and clinical experience.
In particular, my research interests are in elucidating mechanisms by which the oncogene BRAFV600E leads to the invasive behavior in aggressive, metastatic, and iodine-refractory thyroid cancers.
I'm highly committed and motivated to applying my research and effort to patient care, to facilitate innovation, to solve unmet clinical needs, and improve public health.
I was recently awarded from the American Thyroid Association and from the NIH/NCI for Thyroid Cancer Research, Tumor Microenvironment, and BRAFV600E.
My translational research program is aimed:
To identify new prognostic biomarkers and validate therapeutics for treating metastatic/refractory thyroid cancers. To identify pro-metastatic/-angiogenic and metabolic pathways in the microenvironment of BRAFV600E-positive thyroid cancer. To determine the function of lymphatic/blood vessels in thyroid cancer and identify driver clones in the angiogenic microenvironment of thyroid tumors (tumor heterogeneity). To determine the prognostic role of epigenetic markers (e.g. non-coding RNAs) in thyroid cancer. To investigate pathogenesis and molecular basis of “orphan and rare’ cancer disease with angiogenic profile. My laboratory is open to accept international medical students, PhD students, experienced basic researcher, as well as international PhD students, post-docs, and visiting faculties.
I'm genuinely dedicated to advancing translational Thyroid Cancer Research.
Funds: NIH/NCI, American Thyroid Association, Sponsored Research Grants
New and Noteworthy Publications:
Duquette M, Sadow PM, Husain A, Sims JN, Antonello ZA, Fischer A, Song C., Castellanos-Rizaldos E, Makrigiorgos GM, Kurebayashi J, Nose V, Van Hummelen P, Bronson RT, Vinco M, Giordano TJ, Dias-Santagata D, Pandolfi PP, Nucera C. . Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model. Oncotarget. 2015 Dec 15;6(40):42445-67. .
Husain A, Hu N, Sadow PM, Nucera C.. Angiogenesis and cachexia are in the crossroad in advanced thyroid carcinoma with BRAFV600E. Cancer Lett. 2015 Jul 17. pii: S0304-3835(15)00454-1. .
Sadow P, Priolo C, Nanni S, Karreth FA, Duquette M, Martinelli R, Hussain A, Clohessy J, Kutzner H, Mentzel T, Carman CV, Farsetti A, Petri Henske E, Palescandolo E, Macconaill LE, Chung S, Fadda G, Lombardi CP, De Angelis AM, Durante O, Parker AJ, Pontecorvi A, Dvorak H, Fletcher C, Pandolfi PP, Lawler J, Nucera C.. Investigation of the role of BRAFV600E in the first preclinical model of multifocal infiltrating human myopericytoma development and microenvironment, J Natl Cancer Inst. (JNCI) 2014 Jul 25;106(8). .
Antonello Z and Nucera C. . Orthotopic mouse models for the preclinical and translational study of novel targeted therapies against metastatic human thyroid carcinoma with BRAFV600E or BRAFWT. Oncogene 2014 Nov 20;33(47):5397-404. .
Duquette M, Sadow P, Lawler J, Nucera C.. Thrombospondin-1 silencing down-regulates integrin expression levels in human anaplastic thyroid cancer cells with BRAFV600E: new insights in the host tissue adaptation and homeostasis of tumor microenvironment. Front Endocrinol. 2013 Dec 2;4:189. .
Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S.. B-RafV600E and Thrombospondin-1 promote Thyroid Cancer Progression. Proc Natl Acad Sci (PNAS) U S A. 2010;107(23):10649-54..