Katie . Bentley, Ph.D.
Computational Biology Laboratory
Beth Israel Deaconess Medical Center
Harvard Medical School
330 Brookline Avenue, RN-231
Boston, MA 02215
Office Phone: 617-667-0637
Office Fax: 617-667-2913
Katie Bentley earned a PhD in Computer Science from University College London in 2006 investigating morphological plasticity in biological and robotic systems after gaining an interdisciplinary Masters from the University of Sussex in 2002 in evolutionary and adaptive systems. She was awarded a Cancer Research UK postdoctoral fellowship to develop vascular computational models in Paul Bates Biomolecular Modelling Laboratory at the CR UK, London Research Institute in 2006. She was then awarded a Leducq Fondation transatlantic network grant postdoctoral fellowship to work within Holger Gerhardt's Vascular Biology Laboratory and alongside international collaborators in 2009. Katie Bentley was appointed group leader of the Computational Biology Laboratory in the Experimental Pathology Department BIDMC and became a member of the CVBR in 2013.
Research Interests: Computational Modeling of the Vasculature
Basic Research - My laboratory develops and integrates novel computational approaches with in vitro and in vivo experimentation to build a cell dynamic understanding of vascular morphogenesis and pattern formation, with a particular focus on normalizing the abnormal vessels occuring in retinopathy of prematurity The Lab contributes to basic biology by studying vascular development, computational biology by developing novel approaches and revealing fundamental principles and to pathology when investigating the morphogenesis of abnormal blood vessels in disease.
Computationally, the lab integrates multiscale, spatiotemporal computer modeling with automated quantitative image analysis/reconstruction of in vivo microscopy data to reveal the underlying dynamic properties of single to collective endothelial cell movement/behavior in the vasculature.
To drive major transitions in our understanding the laboratory draws inspiration, and is actively involved in, a diverse range of disciplines that synergistically investigate collective adaptive behavior, including evolutionary and collective robotics, diatom/plant morphogenesis, bioengineering and philosophy.
New and Noteworthy Publications:
Kur, E., Kim, J., Tata, A., Comin, C., Harrington, K. I., Costa, L. D., Bentley, K.*, Gu, C.*. Temporal modulation of collective cell behavior controls vascular network topology. eLife (eLife 2016;10.7554/eLife.13212) 2016(2014) The role of differential VE-cadherin dynamics in cell rearrangements in angiogenesis. Nature Cell Biology 16:309-321..
Ubezio, B., Blanco, R., Geudens, I., Stanchi, F., Mathivet, T., Jones, M., Ragab, A., Bentley, K*, Gerhardt, H* (co-last). Collective endothelial Dll4/Notch dynamics switch between vessel branching and expansion, eLife (epub e12167) 2016.
Bentley, K., Franco, C.A. Philippides, A., Blanco, R., Dierkes, M., Gebala, V., Stanchi, F., Jones, M., Aspalter, I. M., Cagna, G., Kutschera, S., Claesson-Welsh, L., Vestweber, D., Gerhardt, H.. (2014) The role of differential VE-cadherin dynamics in cell rearrangements in angiogenesis. Nature Cell Biology 16:309-321..
Bentley,K., Philippides, A., Ravasv Regan, E.. (2014) Do Endothelial Cells Dream of Eclectic Shape? Developmental Cell 29(2):146-158..
Bentley, K., Jones, M., Cruys, B. . (2013) Predicting the future: towards symbiotic computational and experimental angiogenesis research. Experimental Cell Research. In Press Doi: 10.1016/j.yexcr.2013.02.001..
Bentley, K., Gerhardt, H. and Bates, P. A.. (2008) Agent-based simulation of notch mediated tip cell selection in angiogenic sprout initialisation. Journal of Theoretical Biology, 250(1):25-36..